Fri May 12 2023

99 articles - From Friday May 05 2023 to Friday May 12 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Clin Gastroenterol Hepatol

AGA Clinical Practice Update on Interventional EUS for Vascular Investigation and Therapy: Commentary.

Methods This Clinical Practice Update was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. This expert commentary incorporates important as well as recently published studies in this field, and it reflects the experiences of the authors who are advanced endoscopists with expertise in endoscopic ultrasound-guided vascular investigation and therapy.

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Meta-analysis

meta-analyses and systematic reviews

J Hepatol

TIPS prevents further decompensation and improves survival in patients with cirrhosis and portal hypertension in an individual patient data meta-analysis.

The use of TIPS for refractory ascites and for prevention of variceal rebleeding reduces the incidence of a further decompensation event in comparison to SOC and increases survival in highly selected patients. Impact and implication A further decompensation (new or worsening ascites, variceal bleeding or rebleeding, hepatic encephalopathy, jaundice, HRS-AKI and SBP) in patients with cirrhosis is associated with a poor prognosis. Besides the already known role of TIPS in portal hypertension related complications, this study shows that TIPS is also able to decrease the overall risk of a further decompensation compared to standard of care and increases survival. These results strengthen the role of TIPS in the management of patients with cirrhosis and portal hypertension related complications.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

A dose-dependent increase in the risk of inflammatory bowel disease after exposure to broad-spectrum antibiotics: A national population study in Korea.

Broad-spectrum antibiotics dose-dependently increased the risk for IBD in the national population. Our findings provide a fundamental epidemiological basis for identifying antibiotic use as a significant risk factor for IBD across different environmental backgrounds.

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Real-world experience with Curcumin-QingDai combination for patients with active ulcerative colitis: A retrospective multicentre cohort study.

In this real-world cohort, CurQD effectively induced clinical and biomarker remission in patients with active UC, including the biologics/small molecules experienced patients.

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Am J Gastroenterol

Correlation of internal jugular vein (IJV) collapsibility with central venous pressure (CVP) in patients with liver cirrhosis.

IJV CSA-CI at 30º correlated better with CVP (r=-0.56, P=<0.001), and an IJV AP-CI at 30º =24.8% was better at predicting a CVP =8 mmHg, with 100% sensitivity and 97.1% specificity. Thus, IJV POCUS might be superior than IVC POCUS as a predictor of CVP in cirrhotic patients.

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Empiric esophageal dilatation for solid-food dysphagia: presence of mucosal tear on relook endoscopy predicts symptomatic response.

Patients with a mucosal tear following empiric dilatation have a superior symptomatic response to those without, and comparable to patients with visible strictures. We infer the tear represents disruption of an endoscopically inapparent stricture.

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Microscopic colitis and risk of incident acute pancreatitis: A nationwide population-based matched cohort study.

This nationwide study of more than 12,000 patients with MC demonstrated an increased risk of acute pancreatitis after MC. Hence, clinicians should have a low threshold for evaluation of acute pancreatitis in patients with MC. Also, these patients should receive advice and care aimed at reducing the risk of acute pancreatitis.

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Previous SARS-CoV-2 Infection Is Not Associated with Increased Celiac Disease Autoimmunity in Children and Adolescents.

In this large-scale analysis, previous SARS-CoV-2 infection was not associated with celiac disease autoimmunity in Colorado children.

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Clin Gastroenterol Hepatol

A PROTOCOLIZED MANAGEMENT OF WALLED-OFF NECROSIS (WON) REDUCES TIME TO WON RESOLUTION AND IMPROVES OUTCOMES.

A protocolized strategy resulted in faster WON resolution compared to a discretionary approach without the need for additional therapeutic interventions, and with a better safety profile and decreased health care utilization.

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Epidemiologic Burden and Projections for Eosinophilic Esophagitis-Associated Emergency Department Visits in the United States (2009-2030).

The volume of EoE-associated ED visits tripled between 2009 to 2019 and is projected to further double by 2030. This represents a substantial burden of unanticipated healthcare resource utilization and highlights a potential opportunity to optimize outpatient EoE care.

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Fibrosis-4 index predicts long-term all-cause, cardiovascular and liver-related mortality in the adult Korean population.

At the population level, liver fibrosis estimated by FIB-4 was associated with increased cumulative all-cause, cardiovascular and liver-related mortality.

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Impact of PNPLA3 rs738409 polymorphism on the development of liver-related events in patients with non-alcoholic fatty liver disease.

Non-obese female patients with NAFLD 50 years and older, and carrying the PNPLA3 GG risk genotype, are at higher risk of developing liver-related events compared to those with the wild type allele (CC/CG). This finding may have implications in clinical practice for risk stratification and personalized medicine.

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THE SEVERITY OF REDUCED ESOPHAGEAL DISTENSIBILITY PARALLELS EOSINOPHILIC ESOPHAGITIS DISEASE DURATION.

Esophageal distensibility objectively measured with FLIP was reduced in EoE patients with greater symptom duration and diagnostic delay. This supports that EoE is a progressive, fibrostenotic disease and that FLIP may be a useful tool to monitor disease progression in EoE.

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Endoscopy

Metachronous lesions after gastric endoscopic submucosal dissection: First assessment of the FAMISH predicting score.

The FAMISH score might be a concise and useful tool, accurately identifying patients with low-to-intermediate risk for MGL at 3 years of follow-up, who might expand the surveillance interval to reduce the burden of care.

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One-Scope I: Evaluation of a single-use gastroscope in patients presenting with suspected upper gastrointestinal hemorrhage - a pilot feasibility study.

In this feasibility study, we propose a possible niche for single-use gastroscopes in patients presenting for urgent endoscopic evaluation and treatment of upper gastrointestinal bleeding.

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The carbon footprint of ambulatory gastrointestinal endoscopy.

This is the first multi-criteria analysis assessing carbon footprint of gastrointestinal endoscopy. It highlights that travel, medical equipment and energy are major sources of this footprint, waste being a minor contributor. This study provides an opportunity to raise awareness among gastroenterologists of the carbon footprint of GIE procedures.

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Gastroenterology

A Comparison of Risk Classification Systems of Colorectal Adenomas: A Case-Cohort Study.

Using the ESGE2020 and novel risk classifications will substantially reduce resources needed for colonoscopy surveillance following adenoma removal.

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ALKBH5 Drives Immune Suppression via targeting AXIN2 to Promote Colorectal Cancer and is a Target for Boosting Immunotherapy.

Our study identifies an ALKBH5-m 6 A-AXIN2-Wnt-DKK1 axis in CRC which drives immune suppression to facilitate tumorigenesis. Targeting of ALKBH5 is a promising strategy for sensitizing CRC to immunotherapy.

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Effect of Helicobacter pylori Eradication Therapy on the Incidence of Noncardia Gastric Adenocarcinoma in a Large Diverse Population in the United States.

In a large, diverse, community-based population, H. pylori eradication therapy was associated with a significantly reduced incidence of NCGA after 8 years compared with no treatment. The risk among treated individuals became lower than the general population after 7-10 years of follow-up. The findings support the potential for substantial gastric cancer prevention in the U.S. through H. pylori eradication.

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Molecular Profiling Provides Clinical Insights into Targeted and Immunotherapies as well as Colorectal Cancer Prognosis.

Our integrated analysis provides insights into CRC prognostic stratification, drug response, and personalized genomics-guided targeted and immunotherapies.

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Gastrointest Endosc

Combining Transoral Outlet Reduction with Pharmacotherapy Yields Similar One-year Efficacy with Improved Safety Compared to Surgical Revision for Weight Regain Following Roux-en-Y Gastric Bypass.

Combination of TORe with AOM is superior to either therapy alone providing similar efficacy to surgical revision with a better safety profile for the treatment of weight regain following RYGB.

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Effects of Percutaneous Endoscopic Gastrostomy in Patients with Esophageal Squamous Cell Carcinoma During Concurrent Chemoradiotherapy: a Prospective Study.

We found that PEG effectively maintains the body weight and skeletal muscle index of patients with esophageal cancer during CCRT. It also improves the synchronous chemotherapy completion rate and reduces the occurrence of =grade 2 radiation esophagitis.

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Inverse association of hospital volume with in-hospital mortality rate of patients receiving endoscopic ultrasound-guided interventions for pancreatic fluid collections.

Higher hospital volume was associated with a lower risk of in-hospital mortality of patients receiving EUS-guided treatment of PFCs. A further investigation is warranted to justify the volume-based selective referral of the patients.

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Long-term outcome of cervical lymph node metastasis in superficial pharyngeal squamous cell carcinoma after endoscopic submucosal dissection.

Tumor thickness and lymphatic invasion are validated as significant independent predictors for cervical LNM, which can be useful indicators to optimize the therapeutic strategies for superficial PSCC.

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Salvage peroral endoscopic myotomy is a promising treatment for achalasia following a myotomy failure.

Salvage POEM following a previous myotomy failure, especially after POEM failure, is a promising treatment option as it has a durable clinical relief rate.

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Hepatology

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients.

The ability to electively sample and intensively profile the immune landscape of the liver, and generate high-resolution data, will enable multi-site clinical studies to identify biomarkers for intrahepatic immune activity in HBV and beyond.

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Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study.

The safety profile of TXR + CVC combination was similar to respective monotherapies, with no new signals. TXR monotherapy showed sustained ALT and body weight decreases. No substantial incremental efficacy was observed with TXR + CVC combination on ALT, body weight, or in histological endpoints compared with monotherapy.

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Neurogastroenterol Motil

Effect of inter-swallow interval on striated esophagus peristalsis; a comparative study with smooth muscle esophagus.

Striated esophagus peristalsis is subject to manometrically observed inhibition during swallows with ultra-short intervals. Inter-swallow intervals as short as 5 s that inhibit smooth muscle esophagus peristalsis do not inhibit striated muscle peristalsis. The mechanisms of these observations are unknown but may relate to central or myenteric nervous system influences or the effects of pharyngeal biomechanics.

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Enhanced neuron-glia network in the submucosa and increased neuron outgrowth into the mucosa are associated with distinctive expressions of neuronal factors in the colon of rat IBS model.

Neuron network enhancement in the submucosa and neuron outgrowth into the mucosa may be associated with axon guidance factors expressed in hyperplastic EGCs in the colonic submucosa of IBS models.

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MRI tagging of colonic chyme mixing in healthy subjects: Inter-observer variability and reliability of the measurement with time.

MRI tagging technique can provide an assessment of colonic chyme mixing. The inter-observer study data showed high inter-rater agreement. The temporal variation study showed some individual variations with time suggesting multiple measurements may be needed to increase accuracy.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: adjuvanted recombinant zoster vaccine in adults with inflammatory bowel disease-time for universal recommendation?

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Editorial: buspirone for gastroparesis-an intriguing option for a challenging condition.

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Editorial: coeliac disease follow-up guided by gluten immunogenic peptides-are we there yet?

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Editorial: ondansetron for patients with IBS-D and bowel-predominant symptoms.

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Clin Gastroenterol Hepatol

Potential Value of Biomarker-Based Approaches for Evaluation and Management of Costly Functional Gastrointestinal Diseases.

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Gastroenterology

Lynch Syndrome: A Single Hereditary Cancer Syndrome or Multiple Syndromes Defined by Different Mismatch Repair Genes?

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The Ideal Screening Test Is the Test That Is Done.

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Gut

Fungi and cancer.

In all, we demonstrate that fungi likely constitute important members of mucosal and tumour-residing microbiomes. Exploration of fungal inter-kingdom interactions with the bacterial microbiome and the host and decoding of their causal impacts on tumour biology may enable their harnessing into cancer diagnosis and treatment.

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J Hepatol

Changing epidemiology, global trends and implications for outcomes of NAFLD.

This narrative review discusses recent changes in the epidemiology of NAFLD and NASH from regional and global perspectives, as well as in special populations. We also discuss the consequences these changes can have on hepatic and extra-hepatic events.

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Nomenclature, Diagnosis and Management of Drug-induced Autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report.

A management algorithm is proposed. There is an urgent need to prospectively evaluate patients with DI-ALH systematically to enable definitive characterization of this condition.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Endoscopy

A novel cannula with a movable tip facilitates cannulation during endoscopic retrograde cholangiopancreatography in reconstructed intestinal tracts.

Pubmed   Journal   ReadQx   PMC

An unusual case of isolated serum -glutamyl transferase elevation: slight abnormality also should not be taken lightly.

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Defect closure with endoscopic suturing improves endoscopic full-thickness resection of duodenal gastrointestinal stromal tumors.

Pubmed   Journal   ReadQx   PMC

Effectiveness of endoscopic ultrasound-guided drainage procedure for symptomatic lymphocele.

Pubmed   Journal   ReadQx   PMC

Endoscopic submucosal dissection of a large sessile serrated lesion recurrence using an adaptive traction device.

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Endoscopic treatment for a hematoma-mediated colon obstruction caused by acupuncture: A rare case report.

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Gel immersion radial incision and cutting for pancreaticojejunostomy anastomotic stricture.

Pubmed   Journal   ReadQx   PMC

Ileocecal valve-plasty for Crohn's disease: an endoscopic approach.

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Novel protective retrieval bag for safe removal of gastric gastrointestinal stromal tumor after endoscopic full-thickness resection.

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Peroral cholangioscopy-guided transpapillary gallbladder drainage and cholecystolithotomy in the treatment of acute cholecystitis and cholelithiasis.

Pubmed   Journal   ReadQx   PMC

Rare complications related to lumen-apposing metal stent placement, successfully treated by endoscopic hand-suturing device.

Pubmed   Journal   ReadQx   PMC

Segmental absence of the intestinal musculature in the stomach of an adult found during endoscopic submucosal dissection.

Pubmed   Journal   ReadQx   PMC

Stapling peroral endoscopic myotomy over Heller?

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Successful endoscopic closure of a large esophageal perforation using the purse-string technique.

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Successful endoscopic submucosal dissection for a cecal laterally spreading tumor using a motorized spiral enteroscope in a case with difficult intubation.

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Successful retrieval of a fractured biliary guidewire using a newly developed endoscopic tapered sheath.

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The "echo-free space" technique: a safe and reliable method for endoscopic ultrasound scope insertion.

Pubmed   Journal   ReadQx   PMC

Underwater precutting endoscopic mucosal resection using a multifunctional snare for a large colonic laterally spreading tumor.

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Gastroenterology

ChatGPT Answers Common Patient Questions About Colonoscopy.

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How to become a leader as a fellow.

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Multiple ulcerated and polypoid lesions in a renal transplant patient.

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Gastrointest Endosc

A huge colonic intramural hematoma caused by endoscopic submucosal dissection.

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A mucosa-associated lymphoid tissue lymphoma in rectum misdiagnosed as neuroendocrine tumor.

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A rare ulcerative lesion of the duodenum: angiosarcoma.

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A very rare case of isolated collagenous duodenitis.

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Advanced Gastric Adenocarcinoma Misdiagnosed as Gastric Stromal Tumor.

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Delamination of a Lumen Apposing Metal Stent with Tissue Ingrowth and Stent-in-Stent Removal.

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Gastric cancer in Lynch syndrome observed by image-enhanced endoscopy.

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Ig G4-Related Disease: An Unusual Presentation As Collagenous Gastritis.

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Illusion of Endoscopic Success in Instances of Spontaneous Disease Resolution.

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Pancreatoscopy-assisted photodynamic therapy for early pancreatic duct lesions under direct vision.

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Resected specimen extraction using a medical glove in endoscopic submucosal dissection of a large gastric submucosal tumor.

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Schistosomiasis Enteropathy Diagnosed by Real-time Endocytoscopy:A Case Report.

Pubmed   Journal   ReadQx 

THE APPLICATION OF TEXTURE AND COLOR ENHANCED IMAGING FOR ENDOSCOPIC SUBMUCOSAL DISSECTION.

Pubmed   Journal   ReadQx 

UNRECOGNIZED CHRONIC GIARDIASIS DETECTED BY MOTORIZED SPIRAL ENTEROSCOPY: SEEING IS BELIEVING!

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Hepatology

Letter to the Editor: Is there survival bias? The etiologic analysis for the negative association between fatty liver and mortality in the elderly populations.

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Letter to the editor: Modeling concerns.

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Matrisomic characterization of hepatocellular carcinoma to inform individualized patient management.

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Reply: Is there survival bias? The etiologic analysis for the negative association between fatty liver and mortality in the elderly populations.

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Reply: modeling concerns.

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The key role of hepatology providers in optimizing reproductive care in patients with liver disease: a call to action.

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The national hepatitis c elimination program - AASLD's coalition and call to action.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: adjuvanted recombinant zoster vaccine in adults with inflammatory bowel disease-time for universal recommendation? Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: coeliac disease follow-up guided by gluten immunogenic peptides-are we there yet? Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: ondansetron for patients with IBS-D and bowel-predominant symptoms-authors' reply.

Pubmed   Journal   ReadQx 

Letter: 1-kestose, the smallest fructooligosaccharide component, protection for mild to moderate ulcerative colitis patients-authors' reply.

Pubmed   Journal   ReadQx 

Letter: 1-kestose, the smallest fructooligosaccharide component, protection for mild to moderate ulcerative colitis patients.

Pubmed   Journal   ReadQx 

Letter: eosinophilic duodenitis and increased intraepithelial lymphocytes in rumination syndrome - more evidence.

Pubmed   Journal   ReadQx 

Letter: factors influencing discontinuation of aspirin in patients after gastrointestinal bleeding - authors' reply.

Pubmed   Journal   ReadQx 

Letter: factors influencing discontinuation of aspirin in patients after gastrointestinal bleeding.

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Letter: pre-emptive TIPSS and the risks of uncertainty.

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Gastroenterology

This Letter to the Editor is in response to: Microbial Riboflavin Biosynthesis Associates with Response to Dietary Fiber Consumption: Time to Personalize Adjunct Therapy in Patients with Inflammatory Bowel Disease?

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Gut

Revisiting the donor screening protocol of faecal microbiota transplantation (FMT): a systematic review.

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J Hepatol

Caveats to link in vitro mechanistic mitophagy studies to the pathogenesis of non-alcoholic steatohepatitis.

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Defining severe NAFLD based on ICD codes in large cohorts: balancing feasibility and limitations.

Pubmed   Journal   ReadQx 

Fingolimod, a sphingosine-1-phosphate agonist for the treatment of hepatopulmonary syndrome: Queries and concerns.

Pubmed   Journal   ReadQx 

Global incidence of NAFLD: Sets alarm bells ringing about NAFLD in China again.

And we noticed a recent meta-analysis published in your esteemed journal and read it with great interest. We have identified some issues that we believe warrants further attention, which may offer some useful guidance in comprehensively understanding the current status of NAFLD pandemic in China.

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To the Editor: Risk stratification and outcome assessment in randomized controlled trials with machine perfusion.

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Neurogastroenterol Motil

Should we have to include transcutaneous neuromodulation in the therapeutic GERD armamentarium?

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